Category: Therapy


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Hepatitis C treatment cures over 90 percent of patients who also have cirrhosis

Date:
April 12, 2014
Source:
University of Texas Health Science Center at San Antonio
Summary:
Twelve weeks of an investigational oral therapy cured hepatitis C infection in more than 90 percent of patients with liver cirrhosis and was well tolerated by these patients, according to a new study.

Twelve weeks of an investigational oral therapy cured hepatitis C infection in more than 90 percent of patients with liver cirrhosis and was well tolerated by these patients, according to an international study that included researchers from UT Medicine San Antonio and the Texas Liver Institute. Historically, hepatitis C cure rates in patients with cirrhosis (liver scarring) have been lower than 50 percent and the treatment was not safe for many of these patients.

Hepatitis C virus is the No. 1 driver of cirrhosis, liver transplants and liver cancer in the United States, noted Fred Poordad, M.D., lead author on the study, which was released Saturday by The New England Journal of Medicine in conjunction with Dr. Poordad’s presentation of the data at the International Liver Congress in London. UT Medicine is the clinical practice of the School of Medicine at The University of Texas Health Science Center at San Antonio, where Dr. Poordad is a professor of medicine. He is vice president of the Texas Liver Institute in San Antonio.

Interferon previously was the only agent to show effectiveness against hepatitis C, but patients often relapsed and the therapy caused multiple side effects. The new regimen is interferon-free and consists of several agents — ABT-450/ritonavir, ombitasvir, dasabuvir and ribavirin. Twelve weeks after the last dose, no hepatitis C virus was detected in the bloodstream of 91.8 percent of patients who took the pills for 12 weeks. Among patients treated for 24 weeks, 95.9 percent were virus-free 12 weeks after the end of therapy.

 

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 Combination Drug Therapy Amazingly Effective In Tackling Hepatitis C

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ScienceDaily: Your source for the latest research news

 

New combination drug therapy proves very effective in hepatitis C treatments

Date:
April 12, 2014
Source:
Beth Israel Deaconess Medical Center
Summary:
Treatment options for the 170 million people worldwide with chronic Hepatitis C Virus (HCV) are evolving rapidly, although the available regimens often come with significant side effects. Two multi-center clinical trials show promise for a new option that could help lead to both an increase in patients cured with a much more simple and tolerable all oral therapy.

Treatment options for the 170 million people worldwide with chronic Hepatitis C Virus (HCV) are evolving rapidly, although the available regimens often come with significant side effects. Two multi-center clinical trials led by Beth Israel Deaconess Medical Center show promise for a new option that could help lead to both an increase in patients cured with a much more simple and tolerable all oral therapy.

A new 12-week single tablet regimen of ledipasvir and sofosbuvir have proven to be highly effective in treating a broad range of patients with HCV genotype 1, a form of the virus found in up to 75 percent of infections, according to results unveiled today at the European Association for the Study of the Liver and published simultaneously online by the New England Journal of Medicine.

Between 94 percent and 99 percent of patients were cured of hepatitis C and results were similar in patients who have never been treated and for those who had previously been treated with a combination of peginterferon and ribavirin, the current course that carries sometimes significant side effects.

“Eliminating interferon and ribavirin from treatment regimens is expected to reduce the incidence and severity of adverse events, to simplify the treatment of patients with HCV infection and to provide an option for patients who are ineligible for the current interferon-based treatments,” said Nezam Afdhal, MD, the senior author of the studies, Director of the Liver Center at Beth Israel Deaconess Medical Center and a Professor of Medicine at Harvard Medical School.

Hepatitis C is an infectious disease primarily affecting the liver and which can lead to scarring and cirrhosis and is transmitted primarily through blood transfusions (prior to 1991), intravenous drug use, poorly sterilized medical equipment and sexual transmission.. After exposure 80 percent of patients develop a chronic hepatitis which can lead to cirrhosis, liver failure and liver cancer and hepatitis C is the most common cause for liver transplantation in the US.

Prior treatments have been with interferon which is an injectable cytokine released in response to viral infections. Interferon is combined with other antiviral agents and needs to be used for up to 48 weeks to cure hepatitis C. but is associated with number of side effects, including influenza-like symptoms depression and anemia. Many patients are ineligible for these interferon-based therapies.

“The real advances seen in the Ion trials is that the sofosbuvir-ledipasvir combination tablet enables us to treat almost all genotype 1 patients with a short duration of 8-12 weeks of treatment expanding the treatment pool and increasing the overall cure rate,” said Afdhal.

Recent recommendations by the CDC and endorsed by the USPHS Task force have recommended screening of baby boomers (persons born between 1945 and 1965) for hepatitis C since up to3 percent may have silent infection without symptoms.
“Screening for HCV needs to be associated with a safe and effective treatment for these “baby boomers” with newly identified HCV and the ION trials clearly give an exciting new option for these patients” stated Afdhal.

 

 

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Vets, Docs Worry Fort Hood Shootings Will Deepen PTSD Stigma

The word “PTSD” had barely left the mouth of Fort Hood’s commander late Wednesday when, across the nation, many veterans with those symptoms and doctors who treat the malady understood they faced a renewed battle: a resurgence of the stigma that comes with that diagnosis.

The Fort Hood tragedy –- 16 wounded and four killed, including identified shooter Ivan Lopez, a soldier being evaluated for PTSD –- is precisely the type of event that makes combat veterans cringe. Many worry they’ll be further mislabeled as dangerous time bombs, as the next to snap, and that post-traumatic stress will again be misrepresented and misunderstood as a condition that sparks public, violent outbursts.

“That is not what post-traumatic stress is or what it does,” said Ingrid Herrera-Yee, a clinical psychologist in the Washington, D.C. area who treats veterans diagnosed with Post Traumatic Stress Disorder and other mental health issues as well as their family members and civilians. Her husband, Army National Guard Staff Sgt. Ian Yee, spent three combat deployments in Iraq and Afghanistan.

“Yes, there is anger and irritability (associated with PTSD), but it’s usually internalized. You’re more likely to see it as someone who is withdrawn, anxious and numb, who’s lost interest in life. Some veterans explain it to me this way: ‘The last thing you want is to go out and lash out,” said Herrera-Yee, adding: “Just like any victims of a trauma –- rape or domestic violence -– they can become fearful of their surroundings, but they’re not going to react angrily toward their surroundings. For them, it’s all about avoidance.”

“You’re more likely to see it as someone who is withdrawn, anxious and numb, who’s lost interest in life. Some veterans explain it to me this way: ‘The last thing you want is to go out and lash out.’”

For years, Pentagon brass and branch commanders have urged troops and veterans to seek mental-health help if they feel the need, while repeating the message that, if they do see a doctor, they will not be viewed as weak but as strong. That campaign seems to have finally dented the macho-military mantra that every soldier can handle his or her own business. Many veterans are turning to doctors to begin addressing post-service anxiety issues, often fueled by repeated or long deployments.

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Expensive pills
March 29, 2014

There is a little known bill in the works which would force people in crisis into forced psychiatric treatment. Mad in America reported on March 28, 2014 that mental health advocates are urging protest against a forced treatment addition to a new Medicare bill. Many national mental health and disability advocacy groups have joined together to urge people to contact their senators in order to protest a section of a bill which was rushed through the House of Representatives by voice vote this week. This bill, Section 224 of HR4302, is up for a vote in the Senate on Monday.

Raymond Bridge, public policy director of the National Coalition for Mental Health Recovery has said: “In its rush to fix a problem with Medicare, the House passed a bill including a highly controversial program, involuntary outpatient commitment, with no debate and no roll call vote.” It appears to Bridge that the Senate may pass a version of the House bill which includes this troublesome provision on Monday. Daniel Fisher, M.D., Ph.D. has commented about this bill, saying: “It would bring America back to the dark ages before de-institutionalization, when people with mental health conditions languished in institutions, sometimes for life.”

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Mental Health Advocates Decry Forced Treatment Provision in “Doc Fix” Bill

 

WASHINGTON, March 28, 2014 /PRNewswire-USNewswire/ — The bill rushed through the House of Representatives by voice vote yesterday to patch Medicare regulations includes a highly controversial provision that has nothing to do with Medicare, and that would subject people in crisis to forced treatment. Studies have shown that such force causes trauma and drives people away from treatment, mental health advocates warned.

Today, an array of national mental health and disability advocacy groups joined together to decry this provision, which they view as a regressive attack on hundreds of thousands of Americans with serious mental health conditions.

“In its rush to fix a problem with Medicare, the House passed a bill including a highly controversial program, involuntary outpatient commitment, with no debate and no roll call vote,” said Raymond Bridge, public policy director of the National Coalition for Mental Health Recovery (NCMHR), a coalition of 32 statewide organizations and others representing individuals with mental illnesses. “And it seems that the Senate may pass a version of the House bill including this troubling provision on Monday,” Bridge added.

The 123-page Protecting Access to Medicare Act of 2014, H.R. 4302, includes a four-year, $60 million grant program (Sec. 224) to expand involuntary outpatient commitment (IOC) – also called Assisted Outpatient Treatment (AOT) – in states that have laws authorizing IOC. The laws allow courts to mandate someone with a serious mental illness to follow a specific treatment plan, usually requiring medication. The facts show that involuntary outpatient commitment is not effective, involves high costs with minimal returns, is not likely to reduce violence, and that there are more effective alternatives.

Assisted Outpatient Treatment is central to the controversial Helping Families in Mental Health Crisis Act (H.R. 3717), proposed by Rep. Tim Murphy in December 2013.

“This legislation would eliminate initiatives that use evidence-based, voluntary, peer-run services and family supports to help people diagnosed with serious mental illnesses to recover,” said Daniel Fisher, M.D., Ph.D., a psychiatrist and an NCMHR founder. “It would bring America back to the dark ages before de-institutionalization, when people with mental health conditions languished in institutions, sometimes for life.”

The provisions of H.R. 3717 would exchange low-cost, community-based services with good outcomes for high-cost yet ineffective interventions, according to the NCMHR; the National Disability Rights Network (NDRN), the non-profit membership organization for the federally mandated Protection and Advocacy (P&A) Systems and Client Assistance Programs (CAP) for individuals with disabilities; and the National Council on Independent Living (NCIL), which advances independent living and the rights of people with disabilities through consumer-driven advocacy.

 

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Young cancer survivor will get experimental treatment

A 7-year-old boy who has beaten cancer four times but whose weakened immune system is being threatened by a rare virus will start receiving an experimental treatment within 48 hours after the drug’s manufacturer reached an agreement with federal officials for a pilot trial to begin immediately.

The boy, Josh Hardy, will be the first patient to be enrolled Wednesday in the new study of the drug, brincidofovir, the Durham, N.C.-based company, Chimerix, announced late Tuesday.

Earlier the company had said it could not release the drug to Josh outside of clinical trials. The boy’s family had been pleading with the company to change its mind.

1904169-667793373261832-408634175-n.jpg

Josh Hardy is seen in this undated photo from the SaveJosh Facebook page. Used with permission from William Burns
Personal photo

The U.S. Food and Drug Administration agreed to the pilot trial of brincidofovir for the treatment of adenovirus infections in immune-compromised patients, the company said in a statement late Tuesday. The FDA will work expeditiously with Chimerix to design a Phase 3 study that would be a continuation of the pilot trial, the company said.

“Josh Hardy’s story brought to public attention the often-devastating impact of adenovirus infection, and helped accelerate a discussion between the FDA and Chimerix regarding the need for additional clinical development to assess brincidofovir’s potential in adenovirus infection,” Kenneth I. Moch, Chimerix’s president and CEO, said in a statement.

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FORBES

Matthew Herper Forbes Staff

Pharma & Healthcare 3/11/2014 @ 9:12PM 4,486 views

Company Makes Drug Available To Ailing Boy Following Public Outcry

Chimerix, a small and unprofitable biotechnology company, will make an experimental drug available to a young Virginia boy who is suffering from an infection he contracted while being treated for cancer.

Chimerix originally said it could not ethically provide the drug to one patient without opening the floodgates to others, presenting it with a huge operational burden that might prevent the drug, brincidofovir, from ever reaching patients. The story of the boy, Joshua Hardy, was shared on CNN, USA Today, The Huffington Post, and generated a large volume of posts on the social networking site Twitter under the hashtag #savejosh. This evening, Chimerix, based in Durham, North Carolina, issued a press release saying that it was going to start a new, 20-patient clinical trial for the treatment of adenovirus (the virus brincidofovir treats) in immunocompromised patients. The first immunocompromised patient, dosed tomorrow morning, will be Josh Hardy.

“This 20-patient open-label study underscores Chimerix’s mission to develop innovative antiviral therapies in areas of high unmet need – for everyone,” said Chimerix Chief Executive Kenneth I. Moch in his company’s press release. “Being unable to fulfill requests for compassionate use is excruciating, and not a decision any one of us ever wants to have to make. It is essential that each individual in a health crisis be treated with equal gravity and value, a principle we have upheld by pursuing further clinical study of brincidofovir that will inform its use in adenovirus and other serious DNA viral infections.”

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Lucas Camacho

Even a $1 donation will help make a difference.  Help make a difference Today.

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Join me in my efforts to support Jump Rope For Heart or Hoops For Heart! Even the smallest of donations make a big difference.

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I need your support!Hi,

We only have one heart! I want to take care of mine and help you take care of yours too! This year, I have set a personal goal to raise money for the American Heart Association at my school.
Heart Disease can happen to anyone so it’s really important to be physically active and eat healthy. Did you know that heart disease is our nation’s number one killer? Help me become a lifesaver!
Will you make a donation to help me reach my goal? It’s fast and easy to do on my personal webpage. Just use the link below to support me today!
Your contribution will support the American Heart Association’s work to:
- Put up-to-the-minute research into doctors’ hands so they can better prevent and treat heart disease among patients.
- Fund groundbreaking pediatric heart and stroke research.
- Train more than 9 million health professionals and others each year in emergency cardiovascular care.
Please support me in my efforts – together we can save lives! Thank you very much!

Follow This Link to visit my personal web page and help me in my efforts to support YM-GSA

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I’m joining millions of others to help save lives with the American Heart Association!

At my school, I’m learning how I can help make a difference by raising lifesaving donations to help kids with heart disease. I’m also learning about my own heart, and how to keep it healthy. And I’m getting active!

I’m excited about raising money for other kids – kids with hearts that don’t exactly work right and to help fund new medicines and treatments to be discovered.

Please help me make a difference! Thank you!

Welcome to the Donation Page of

Lucas Camacho

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Vitamin C, Shingles, and Vaccination

by Thomas E. Levy, MD, JD

The pharmaceutical industry, and many doctors, appear to be making great efforts by to get as many people as possible vaccinated against shingles. Even if such an intervention was highly effective in preventing shingles, which certainly has not been shown to be the case, the information below should make it clear that such vaccinations are unnecessary. The side effects that would be suffered by a significant number of individuals need never occur in the first place. The real problem is that what is discussed below generates relatively little income for anybody in the healthcare industry. Regardless, you need to decide for yourself.

Shingles is an infection resulting from the varicella zoster virus, usually manifesting in areas supplied by spinal nerves, known as dermatomes. More commonly known in medical circles as Herpes zoster, the infection is typically characterized by a blistering skin rash of extraordinary pain for most individuals. The initial infection with the virus is usually remote from the shingles outbreak, typically occurring in childhood when chickenpox is contracted. For years the virus remains latent in nerve cell bodies or autonomic ganglia. It is when the virus, for unclear reasons, breaks out of these storage sites and travels down the nerve axons that shingles occurs.

Left to itself along with mainstream therapies that include analgesics, antiviral agents like acyclovir, and corticosteroids, the rash will generally resolve in two to four weeks. The pain is generally lessened little by analgesics. Some unfortunate individuals can experience postherpetic neuralgia, a syndrome of residual nerve pain that can continue for months or years following a shingles outbreak.

Treatment of Shingles with Vitamin C

The clinical response of shingles to vitamin C therapy is decidedly different from its response to traditional therapies. While there are not many reports in the literature on vitamin C and shingles, the studies that do exist are striking. Frederick Klenner, MD, who pioneered the effective use of vitamin C in a wide variety of infections and toxin exposures, published the results of his vitamin C therapy on eight patients with shingles. He gave 2,000 to 3,000 mg of vitamin C by injection every 12 hours, supplemented by 1,000 mg in fruit juice by mouth every two hours. In seven of the eight patients treated in this manner, complete pain relief was reported within two hours of the first vitamin C injection. All patients received a total of five to seven vitamin C injections. Having had shingles myself years before I knew of the efficacy of vitamin C therapy, I can assert that this is nothing short of a stunning result on what is usually a painful and debilitating disease.

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• Andrew Cuomo in surprise reverse of hardline position

• Small but significant change to highly restrictive laws

Governor Andrew Cuomo
Governor Andrew Cuomo at the inauguration of New York City’s Mayor Bill de Blasio on January 1, who has set a liberal agenda. Photograph: Spencer Platt/Getty Images

New York is poised to become the latest US state to relax its laws covering marijuana. Governor Andrew Cuomo will make a surprise turnaround in policy later this week, to allow limited use of the drug for medical purposes.

As Colorado residents continue to flock to their local pot shops, after their state became from 1 January the first to allow the sale and possession of cannabis for recreational purposes, signs have emerged that New York will now make a small but important amendment to some of the strictest laws on the drug in the US. Cuomo is expected to announce an executive action in his annual state of the state address on 8 January, to permit a small number of hospitals to prescribe marijuana for medical use in the treatment of serious illnesses including cancer and glaucoma, the New York Times reported on Sunday.

Cuomo, a Democrat, has always been staunchly against legalising cannabis, including for medical use. Even though the likely announcement would only loosen restrictions on the drug very slightly, it will be seen as a significant move at a time when a number of states are liberalising their laws in ways ranging from the use of medical marijuana to decriminalising basic possession of the drug, up to full recreational use. Voters in Washington state have also voted to allow recreational marijuana and it is expected to follow Colorado later this year and become the second state to implement such laws.

More than 20 states currently have laws allowing a variety of medical uses of marijuana.

Cuomo is expected to emphasise that medical marijuana will only be allowed for a tightly circumscribed list of illnesses, to be drawn up by the state Department of Health.

By announcing a unilateral executive action, the governor will sidestep the legislative process in the state capital, Albany, where the senate has repeatedly struck down bills passed in the lower assembly to permit medical marijuana.

Ethan Nadelmann, the executive director of the Drug Policy Alliance, told the New York Times Cuomo’s move was “bold and innovative”.

Even limited medical marijuana use is banned under federal law but the Obama administration has signalled that it is not interested in actively pursuing prosecution in states that have relaxed their laws around the drug. Whether there will be any clash between federal law enforcement and state authorities in Colorado and Washington state remains to be seen.

 

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NHK Documentary: “Origins of Disease Episode 3: Depression – Legacy of the Survival Instinct”-

MissingSky101 MissingSky101

 

Published on Nov 17, 2013

Depression causes people to feel sad or down for a long period of time. More than 350 million people suffer from this disease worldwide. Depression was once considered an illness of the mind. But doctors have found physical abnormalities in the brains of people being treated for depression. Now scientists are coming up with a range of treatments, including one that directly controls brain function. How can we overcome depression? We’ll look into the origins of this all-too-common disease.

I apologize for the poor quality of the video. The problem is a broadcast issue.

Thank you to the special person who requested this upload :)

 

 

 

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breakingtheset

 

Published on Nov 19, 2013

Abby Martin speaks with musical artist Moby, discussing his activism, the failures of the corporate music industry, and why he is a vegan.

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FOLLOW Abby Martin @ http://twitter.com/AbbyMartin

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