Grape Seed Extract Superior To Blockbuster Diabetes Drug, Preclinical Study Finds
Saturday, September 14th 2013 at 5:45 am
A new study published in the Journal of Cell Communication and Signaling compared the effects of a grape seed extract (GSP) to the diabetes drug metformin (MET) in rats fed a high fat, high fructose diet (HFFD) designed to provoke insulin resistance.
Titled, “Grape seed proanthocyanidins and metformin act by different mechanisms to promote insulin signaling in rats fed high calorie diet,” Indian researchers discovered that both substances reduced elevated blood glucose (hyperglycemia) and elevated blood insulin (hyperinsulinemia), while improving the following diet-altered parameters: glycolysis, tyrosine phosphorylation of IR-β and IRS-1, IRS-1-PI3K association and Akt activation.
Furthermore, adverse changes induced by the HFFD, such as the activation of tumor necrosis factor-α, interleukin-6, leptin and suppression of cytokine signaling-3 and reduction in adiponectin, were reversed by GSP more effectively than by MET.
Proanthocyanidins are a type of secondary plant metabolites known as flavonoids found in many plants, but are particularly concentrated in cocoa beans, cinnamon, grape seeds and skin, and maritime pine bark (pycnogenol). Proanthrocyanidins are known primarily through their antioxidant properties, but the GreenMedInfo.com research project has identified at least 20 beneficial physiological actions to this phytochemical class relevant to at least 50 disease states.